Maria Scuto


Department of Biomedical and Biotechnological Sciences

University of Catania




Dr. Maria Scuto enrolled in March 2002 the degree course in Biological Sciences at the University of Catania. On October 13th, 2010 she graduated in Cellular and Molecular Biology with a score of 110/110. During the fifth and sixth year of her studies, she attended the Institute of Animal Biology at the University of Catania, where she developed the experimental thesis entitled "Intranuclear localization of human chromosomes 13 and 21 involved in a robertsonian translocation”.
From 2011 to 2015 she attended the Ph.D. Course in Neurobiology at the University of Catania. On February 13th, 2015 she successfully passed the final exam for the achievement of the title of Ph.D. in Neurobiology, discussing a thesis entitled "Mitochondrial biogenesis, misfolding and cellular stress response in aging and in neurodegenerative disorders: proteomic approach ". In 2017 she was awarded a research grant on the project "Regulation of miRNA, neuroinflammation and cellular stress response in neurodegeneration: from bench to clinics ".
Since 2011, Dr. Maria Scuto has been actively collaborating with Prof. Vittorio Calabrese, Department of Biomedical and Biotechnological Sciences, University of Catania. The quality and the productive results of the work carried out by Dr. Scuto are evidenced by the numerous scientific publications in prestigious international journals. In addition, Dr. Scuto has collaborated in multiple educational activities, as co-tutor for graduate students of the Degree Courses in Chemistry, Biological Sciences, and Biomedical Laboratory Techniques and trainees of the Degree Course in Medicine and Surgery. During these years Dr. Maria Scuto has conducted with great diligence, considerable commitment, and critical knowledge of the carrying out of the study and scientific research activities concerning the role of oxidative stress and its modulation by nutritional antioxidants in aging, neurodegenerative and metabolic diseases, both in in vitro and in vivo models.

Area of Interests

  1. Role of Heat shock Proteins and oxidative stress in aging, neurodegenerative disorders, cancer, and metabolic disease in vitro and in vivo models.

  2. Antiaging medicine and the role of nutraceuticals, such as antioxidant mushrooms, redoxomic, and lipidomic analysis in neurodegeneration.

  3. Role of hormesis, brain resilience, and modulation of vitagene pathway as crucial mechanisms for mental health in neurodegeneration and neuropsychiatric disorders.

  4. Mediterranean diet and olive oil polyphenols (Oleuropein, Hydroxytyrosol, and Hydrox) as neuroprotective agents in experimental models of neurodegeneration (C. elegans and mice).

  5. Redox-sensitive modulation of cytoprotective genes by antioxidant polyphenols.

  6. Functions and regulation of adaptative response to enviromental stressors mediated by the Keap1/Nrf2 signaling pathway.